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Stefan Judex , Ph.D.
Associate Professor of Biomedical Engineering.
Funding through the National Aeronautics and Space Administration (NASA)
and the National Space Biomedical Research Institute (NSBRI).
Figure 1. Micro-computed tomography
images of the distal femur from three genetically distinct strains
of mice. While the differences in bone quantity and morphology
are obvious, we have recently demonstrated that these strains
of mice also respond differentially to applied mechanical signals.
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Our interdisciplinary research focuses on how the mass and morphology
of organ systems, such as the skeleton, is regulated and how the quantity
and quality of these systems can be enhanced by physiologic stimuli. Specifically,
we are interested in the complex genetic, molecular, and chemical basis
of the sensitivity of the skeleton to both anabolic and catabolic mechanical
signals. Applications of this work are targeted towards the detection
and treatment of bone diseases such as osteoporosis.
Current projects that IBRP students can take on include (but are certainly
not limited to):
- Linking bone’s mechanical properties to its chemical matrix
composition.
- What are the molecular players defining bone mass and morphology?
- What is the genetic basis for bone’s sensitivity to physiologic
catabolic and anabolic stimuli?
- What is the effect of genetic variations on the transduction of mechanical
stimuli from the organ to the cell?
- Defining bone’s mechanical environment at the micro-structural
level.
Our assays span a great range of experimental techniques from molecular
and genetic, to chemical and mechanical analyses. Hence, students should
have a strong grasp of either the biological, physical, or engineering
sciences and will be awarded with cutting-edge research in a multidisciplinary
team environment.
Contact Information
email: stefan.judex@sunysb.edu
url: http://www.bme.sunysb.edu/bme/people/faculty/s_judex.html
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