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Stanislaus S. Wong, Ph.D.
Assistant Professor, State University of New York
at Stony Brook, Department of Chemistry; Assistant Scientist, Materials
and Chemical Sciences Department, Brookhaven National Laboratory (BNL),
Building 480. Member of the Biomedical Engineering Program and the Biophysics
Program at SUNY Stony Brook.
Funding through the National Science Foundation, American Chemical Society
Petroleum Research Fund, and 3M.
Figure 1. Nanotubes as Chemically
and Biologically-Sensitive Probes. Image shows biotin immobilized
on a nanotube tip interacting with streptavidin-coated surface. |
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We are an interdisciplinary laboratory interested in exploring problems
at the boundary of chemistry, physics, and biology at the nanoscale. Indeed,
working on the nanometer scale, one billionth of a meter, requires the
ability to synthesize, manipulate, and organize matter in a controllable
manner as well as to predict and understand the properties of the resulting
structure. We are interested in understanding important scientific problems,
such as (a) binding energies on surfaces, essential for the design of
effective catalysts; (b) electrostatic and van der Waals forces, significant
for understanding biochemical processes as well as phenomena such as chemical
and biological self-assembly; and (c) interfacial forces (such as adhesion),
which play a role in many industrial and chemical processes.
Current projects include the following. (a). Chemical and biological
functionalization of nanostructures, i.e. controlled placement of moieties,
such as metal-containing complexes, on the surfaces of these materials,
such as carbon nanotubes, in order to change their chemical, electrical,
and mechanical properties in a reproducible and measurable manner. (b).
Imaging topography of biomolecular structures, such as proteins. Use of
chemically specific probes in order to spatially map out, in high-resolution,
domains of a particular functionality on heterogeneous surfaces. Such
information can conceivably be correlated with studies of biological activity
for instance in order to further understanding of structure-property correlations.
(c). Generating ‘tiny’ nanostructures (less than 10 nm) using
a number of different physical methodologies.
Students with a bioengineering and/or chemical/physical sciences background
will be introduced to the use of a vast array of microscopy (electron
and atomic force), X-ray diffraction, and spectroscopy (Raman, UV-visible-near-IR,
fluorescence) techniques both at Stony Brook as well as Brookhaven National
Laboratory. Trainees will learn chemical sample preparation techniques
as well as details of various characterization analyses.
Contact Information
email:
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